Replicatns are like any other machine - they're either a benefit or a hazard.

                If they're a benefit, it's not my problem.

Advances in genetic technology have allowed scientists to create sophisticated biologically-engineered humanoid beings called replicants. Following a violent revolt that takes place "off world", replicants are declared illegal on Earth.

In LA, November 2019, Rick Deckard is called out of retirement when a fellow Blade Runner, Holden is shot administering a Voight Kampff to Leon, an escaped replicant. A reluctant Deckard is brought to his old boss Bryant), who informs him that the recent escape of Nexus-6 replicants is the worst yet. He orders Deckard to eliminate the four replicants, a process referred to as "retirement". Deckard agrees to help after Bryant makes thinly-veiled threats...

Bryant briefs Deckard on the replicants: Roy Batty, the leader, is a "combat model"; Leon Kowalski is a nuclear fuel loader; Zhora, an assassin built for martial arts; and Pris. Bryant also explains that the Nexus-6 model has a four-year lifespan as a failsafe to prevent them from developing their own emotions and desire for independence. Deckard is then teamed up with Gaff and sent to the Tyrell Corporation to ensure that the Voight-Kampff test works on Nexus-6 models. While there, Deckard discovers that Tyrell's young assistant Rachael is an experimental replicant who believes she is a human; Rachael's consciousness has been enhanced with implanted memories from Tyrell's niece, an accomplishment that Tyrell seems most pleased with.

Deckard and Gaff search Leon's apartment as Roy and Leon enter the eye manufactory of Chew; under interrogation, Chew directs them to JF Sebestian as their best chance of meeting Tyrell himself. Roy's master plan to meet his maker is hampered by the urgency created by his limited lifespan, he is exhibiting symptoms of his impending death, his fingers have begun to lose life. Later, Rachael visits Deckard at his apartment to prove her humanity to him, but leaves in tears after Deckard tells her that her memories are in fact implants. Meanwhile, Pris meets J.F. Sebastian and he invites her into his apartment, where he lives alone with his manufactured companions.

Deckard goes to Animoid Row to analyze a scale found in Leon's bathroom, which belonged to a snake made by Abdul Ben Hassan. After a rough interrogation, the snake dealer directs Deckard to a sleazy strip club owned by Taffey Lewis, who employs Zhora. After a struggle in Zhora's changing room a chase through the crowded streets ensues and Deckard shoots and "retires" Zhora. Deckard meets with Bryant shortly after and is told to add Rachael to his list of retirements after she has disappeared from the Tyrell Corporation Headquarters. Deckard spots Rachael in the crowd and follows her, but is grabbed and beaten nearly to death by Leon. However, Rachael saves Deckard's life by shooting Leon, and they head back to his apartment where they become intimate.

Back at Sebastian's apartment Roy arrives, kisses Pris deeply and tells her they are the only ones left. Then he and Pris employ Sebastian's help by explaining their plight in a very subtle, yet threatening manner. In a stroke of irony, Roy discovers that the human Sebastian is suffering from a genetic disorder that accelerates his own aging. Roy sympathizes with Sebastian because of their common fate. Using Sebastian, under the pretext of enticing Tyrell with a chess move for a game Sebastian and Tyrell were engaged in, Roy gains entry to Tyrell's penthouse. Once inside, Roy demands an extension to his lifespan from his maker. Tyrell refuses to help because of limitations of mother nature that even he can't overcome. Roy then asks for his absolution for his sins, confessing that he has done "questionable things". Tyrell arrogantly dismisses this, praising Roy's advanced design and his amazing accomplishments. He tells Roy to "revel in his time". Roy kills Tyrell and Sebastian.

Deckard arrives at Sebastian's apartment and is ambushed by Pris. Deckard manages to grab his gun and retires Pris, just as Roy returns. Roy is horrified at the loss of Pris. Angrily, Roy traps Deckard in the apartment, hunting him throughout the dilapidated building and eventually forcing him to the roof. The symptoms of Roy's limited lifespan worsen and his right hand begins to cramp up, so he jabs a nail through it to regain control. As Deckard attempts to escape Roy, he leaps across to another building but falls short and ends up hanging from a rain-slicked beam. Roy easily vaults the same distance and is left standing above his struggling opponent. Just as Deckard finally loses his grip, Roy seizes his arm and hauls him onto the roof, saving Deckard.

Roy then dies peacefully – his four year lifespan is up. Deckard is left reflecting when Gaff, who arrives after the duel, calls from a distance, "It's too bad she won't live; but then again, who does?" A worried Deckard returns to his apartment and is relieved to find Rachael alive.....

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