I Am Legend

    All right, let me tell you about your "God's plan". Six billion people on Earth

        when the infection hit. KV had a ninety-percent kill rate, that's five

                     point four billion people dead.

After the outbreak of a lethal virus in 2009, US Army virologist Lietenant Colonel Robert Neville is left as the last healthy human in New York City and possibly the entire world.

Opening in 2012, a series of fflashbacks and recorded news programs reveal that in 2009 a genetically re-engineered measls virus, originally created as a cure for cancer, mutated into a lethal strain which rapidly infected humans and animals. By the end of the year, over 90% of the planet's human population had been killed. Over 9% were infected, but did not die. These survivors degenerated into a primal state of aggression and began to react painfully to UV radiation, forcing them to hide in buildings and other dark places during the day. Less than 1% remained completely immune to the virus, but were hunted and killed by the infected until, three years after the outbreak, Robert Neville is left as what he believes to be the last healthy human in the world.

Neville's daily routine includes experimentation to find a cure for the virus and trips through a Manhattan devoid of humanity to hunt for food and supplies. He also waits each day for a response to his continuous recorded radio broadcasts, which instruct any uninfected survivors to meet him at midday at the a certified point. Flashbacks reveal that his wife and daughter appear to have died in a helicopter accident during the chaotic evacuation of Manhattan, prior to the military-enforced quarantine of the island in 2009. Neville's isolation is broken only by the companionship of his dog Sam, interaction with mannequins that he has set up as patrons of a video store, and recordings of old news and entertainment broadcasts.

Neville seems to find a promising treatment derived from his own blood, so he sets a trap and captures an infected woman, while an infected male watches from the shadows. Back in his laboratory, located in the basement, Neville treats the infected woman without success. Shortly thereafter, he is ensnared in a trap similar to the one he used to capture the woman. By the time Neville has escaped, it is dark and he is attacked by infected dogs, one of which bites Sam (Unlike humans, all dogs are immune to the airborne strain, but are still susceptible to the contact strain). When she later begins to show signs of infection, Neville kills her. Later that night he goes out and recklessly attacks a group of infected. He is nearly killed, but is rescued by a pair of immune survivors, Anna and a young boy named Ethan, who have traveled after hearing one of his broadcasts. They take the injured Neville back to his home, where Anna explains that they survived the outbreak and are making their way to a rumored survivors' camp in Vermont.

Neville once again attempts to administer a potential cure to the infected woman in his laboratory, but the next night, a group of infected attack the house and overrun its defences. Neville, Anna, and Ethan retreat into the basement laboratory, sealing themselves in with the woman Neville has been treating. Discovering that the last treatment has been successful, Neville draws a vial of the woman's blood and gives it to Anna. He pushes Anna and Ethan into an old coal chute, then sacrifices himself to save their lives, using a hand grenade to kill the attacking infected.

Anna and Ethan escape to Vermont and locate the survivors' colony, where Anna hands over the cure. In the closing scenes, she states that Neville's cure enabled humanity to survive and rebuild, establishing his legend.

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