In the town of Ogden Marsh, Iowa, David,
the local sheriff enjoys a baseball game. His deputy, Russell, spots Rory
Hamill, a local resident, entering the outfield holding a shotgun. David is
forced to shoot and kill the unresponsive Rory. David and his wife Judy, the
community doctor, begin to notice other town residents exhibiting bizarre
behavior. The next night, a local farmer burns his house down with his wife and
son trapped inside, killing them.
While investigating the discovery of a pilot's body in a swamp, David and
Russell discover a cargo plane submerged under the water. Communication services
are lost, and soldiers arrive to take all residents to quarantine at the high
school. Everyone is examined for symptoms of infection. Judy does not pass the
examination and is separated from David. She explains her fever is due to
pregnancy, but is sedated anyway. She wakes strapped to a gurney as the perimeter of the facility is breached by
the infected. The military personnel evacuate, leaving Judy and others behind.
David is nearing evacuation, but escapes and rejoins Russell. They rescue Judy
and her hospital assistant, Becca.
David, Judy, Russell, and Becca make their way out of town on foot, unable to
find a working vehicle. They encounter Becca's boyfriend, Scotty, when they pass
through his farm. Soldiers raid the farm, shoot Scotty and his mother, and burn
the bodies. The group repair a patrol car, and once on the road are spotted by
an attack helicopter and drive into a car wash for cover. Infected attack and
kill Becca, and the helicopter destroys the car. On foot, Russell disables a
passing government SUV with a police spike strip. The driver, presumably a government
agent, reveals the cargo plane contained "Trixie," a "Rhabdoviridae prototype" biological weapon.
Enraged, Russell shoots the driver and threatens Judy and David. When confronted
about his behavior, Russell realizes he is infected and after being disarmed,
begs to go on with Judy and David, later dying while distracting soldiers at a
blockade, so Judy and David can sneak past.
David and Judy arrive at a truck stop to search for a vehicle, discovering
the military also executed those who were evacuated. Fending off infected, they
escape in a semitruck. Ogden Marsh is destroyed in a huge explosion as they
flee, and their truck flips in the passing shockwave. As the couple walk towards
Cedar Rapids,
a view from a military satellite highlights the city, and the words "initiate
containment protocol" appear, signifying another containment attempt.
In the credits, a news clip is shown in which the newscaster reports that an
explosion originating from the Dakon Petrol chemical plant started a massive
fire in Ogden Marsh, "with eyewitness reports of a 400-foot fireball that lit up
the sky." He goes on to report a second explosion at a nearby truck fueling
station, alluding to the truck stop. He says a perimeter has been set and
civilians are not being allowed into the area. After that, the news clip cuts to
a soldier, and then to a snarling.
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